Effect of 6-mercaptopurine on Endotoxin Tolerance.
نویسندگان
چکیده
منابع مشابه
Effects of phenobarbital and endotoxin on the lethality and metabolism of 6-mercaptopurine in male BALB/c mice.
In male BALB/c mice, a combination of individually non-lethal doses of 6-mercaptopurine and endotoxin was significantly lethal. In contrast, mice treated with phenobarbital were resistant to this lethal effect. The high levels of thioinosinic acid in mice that were treated with endotoxin contrasted significantly with the levels in phenobarbital-treated mice. On the other hand, the concentration...
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Studies presented in this report are concerned with the effect of endotoxin upon the release of bactericidal antibodies as determined by the agar plaque technique. We found that shortly after the injection of mice with small amounts of endotoxin the number of plaque-forming cells in the spleen was substantially reduced and remained low for about 12 hr. At the same time the titer of specific bac...
متن کاملMercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.
BACKGROUND Patients with acute lymphoblastic leukemia are often treated with 6-mercaptopurine, and those with homozygous deficiency in thiopurine S-methyltransferase (TPMT) enzyme activity have an extreme sensitivity to this drug as a result of the accumulation of higher cellular concentrations of thioguanine nucleotides. We studied the metabolism, dose requirements, and tolerance of 6-mercapto...
متن کاملThe effect of 6-mercaptopurine and allopurinol on granulopoiesis.
The effect on granulopoiesis of 6-mercaptopurine alone, and in combination with allopurinol, was studied in mice using an in vitro colony-forming assay for granulocytic progenitor cells. The combination of 6-mercaptopurine and allopurinol pro duced significantly greater suppression of de novo granulo poiesis than did 6-mercaptopurine alone. Allopurinol in very high doses was found to be myelosu...
متن کاملThe failure of allopurinol to enhance 6-mercaptopurine toxicity in rabbits.
We have evaluated the effect of allopurinol on the hematopoietic toxicity of 6-mercaptopurine in rabbits by studying the development of neutropenia in animals that received only 6-mercaptopurine and in those that received both drugs. The studies showed that, rather than demonstrat ing any potentiation of 6-mercaptopurine toxicity, allopurinol protected the animals, as evidenced by less weight l...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 44 شماره
صفحات -
تاریخ انتشار 1965